Cargando…

Staphylococcus aureus RnpA Inhibitors: Computational-Guided Design, Synthesis and Initial Biological Evaluation

Antibiotic resistance is spreading worldwide and it has become one of the most important issues in modern medicine. In this context, the bacterial RNA degradation and processing machinery are essential processes for bacterial viability that may be exploited for antimicrobial therapy. In Staphylococc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suigo, Lorenzo, Chojnacki, Michaelle, Zanotto, Carlo, Sebastián-Pérez, Victor, Morghen, Carlo De Giuli, Casiraghi, Andrea, Dunman, Paul M., Valoti, Ermanno, Straniero, Valentina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071009/ https://www.ncbi.nlm.nih.gov/pubmed/33920000 http://dx.doi.org/10.3390/antibiotics10040438

Ejemplares similares

Optimization of 2-Acylaminocycloalkylthiophene Derivatives for Activity against Staphylococcus aureus RnpA
por: Chojnacki, Michaelle, et al.
Publicado: (2021)

Benzamide Derivatives Targeting the Cell Division Protein FtsZ: Modifications of the Linker and the Benzodioxane Scaffold and Their Effects on Antimicrobial Activity
por: Straniero, Valentina, et al.
Publicado: (2020)

Identification of Small Molecule Inhibitors of Staphylococcus aureus RnpA
por: Colquhoun, Jennifer M., et al.
Publicado: (2019)

Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ
por: Casiraghi, Andrea, et al.
Publicado: (2020)

Computational Design and Development of Benzodioxane-Benzamides as Potent Inhibitors of FtsZ by Exploring the Hydrophobic Subpocket
por: Straniero, Valentina, et al.
Publicado: (2021)

Resolution via diastereomeric amides of enantiopure 1,4‐benzoxathian‐2‐ and 3‐carboxylic acids and determination of their configuration
por: Straniero, Valentina, et al.
Publicado: (2022)

Small Molecule Inhibitors of Staphylococcus aureus RnpA Alter Cellular mRNA Turnover, Exhibit Antimicrobial Activity, and Attenuate Pathogenesis
por: Olson, Patrick D., et al.
Publicado: (2011)

Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson’s Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice
por: Casiraghi, Andrea, et al.
Publicado: (2022)

Construction of a recombinant avipoxvirus expressing the env gene of Zika virus as a novel putative preventive vaccine
por: Zanotto, Carlo, et al.
Publicado: (2021)

Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits
por: Radaelli, Antonia, et al.
Publicado: (2010)

Construction and characterisation of a recombinant fowlpox virus that expresses the human papilloma virus L1 protein
por: Zanotto, Carlo, et al.
Publicado: (2011)

L1R, A27L, A33R and B5R vaccinia virus genes expressed by fowlpox recombinants as putative novel orthopoxvirus vaccines
por: Pacchioni, Sole Maria, et al.
Publicado: (2013)

Disease mutations in the prion-like domains of hnRNPA1 and hnRNPA2/B1 introduce potent steric zippers that drive excess RNP granule assembly
por: Shorter, James, et al.
Publicado: (2013)

Fowlpoxvirus recombinants coding for the CIITA gene increase the expression of endogenous MHC-II and Fowlpox Gag/Pro and Env SIV transgenes
por: Bissa, Massimiliano, et al.
Publicado: (2018)

Genetic Determinants of Acinetobacter baumannii Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance
por: Young, Mikaeel, et al.
Publicado: (2023)

Protection of mice against the highly pathogenic VV(IHD-J) by DNA and fowlpox recombinant vaccines, administered by electroporation and intranasal routes, correlates with serum neutralizing activity
por: Bissa, Massimiliano, et al.
Publicado: (2016)

Systemically administered DNA and fowlpox recombinants expressing four vaccinia virus genes although immunogenic do not protect mice against the highly pathogenic IHD-J vaccinia strain
por: Bissa, Massimiliano, et al.
Publicado: (2013)

Genomics of Staphylococcus aureus ocular isolates
por: Johnson, William L., et al.
Publicado: (2021)

Messenger RNA Turnover Processes in Escherichia coli, Bacillus subtilis, and Emerging Studies in Staphylococcus aureus
por: Anderson, Kelsi L., et al.
Publicado: (2009)

A prime/boost strategy using DNA/fowlpox recombinants expressing the genetically attenuated E6 protein as a putative vaccine against HPV-16-associated cancers
por: Bissa, Massimiliano, et al.
Publicado: (2015)

Staphylococcus aureus gene expression in a rat model of infective endocarditis
por: Hanses, Frank, et al.
Publicado: (2014)

Production of functional, stable, unmutated recombinant human papillomavirus E6 oncoprotein: implications for HPV-tumor diagnosis and therapy
por: Illiano, Elena, et al.
Publicado: (2016)

The Staphylococcus aureus SrrAB Two-Component System Promotes Resistance to Nitrosative Stress and Hypoxia
por: Kinkel, Traci L., et al.
Publicado: (2013)

The HPV E2 Transcriptional Transactivation Protein Stimulates Cellular DNA Polymerase Epsilon
por: Chojnacki, Michaelle, et al.
Publicado: (2018)

The human papillomavirus DNA helicase E1 binds, stimulates, and confers processivity to cellular DNA polymerase epsilon
por: Chojnacki, Michaelle, et al.
Publicado: (2018)

Repurposing the Antihistamine Terfenadine for Antimicrobial Activity against Staphylococcus aureus
por: Perlmutter, Jessamyn I., et al.
Publicado: (2014)

Rapid detection of vaccinia virus using biofunctionalized fiber-optic ball-tip biosensors
por: Rakhimbekova, Aida, et al.
Publicado: (2023)

Multiple Sclerosis-Associated hnRNPA1 Mutations Alter hnRNPA1 Dynamics and Influence Stress Granule Formation
por: Clarke, Joseph-Patrick W. E., et al.
Publicado: (2021)

Diabetic Mouse Model of Orthopaedic Implant-Related Staphylococcus Aureus Infection
por: Lovati, Arianna B., et al.
Publicado: (2013)

Methicillin-resistant Staphylococcus aureus in Cat and Owner
por: Vitale, Carlo B., et al.
Publicado: (2006)

Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors
por: Young, Mikaeel, et al.
Publicado: (2022)

A High-Throughput Screening Approach To Repurpose FDA-Approved Drugs for Bactericidal Applications against Staphylococcus aureus Small-Colony Variants
por: Trombetta, Ryan P., et al.
Publicado: (2018)

Monoclonal antibody against H1N1 influenza virus hemagglutinin cross reacts with hnRNPA1 and hnRNPA2/B1
por: Guo, Chunyan, et al.
Publicado: (2020)

The Staphylococcal Accessory Regulator, SarA, is an RNA-Binding Protein that Modulates the mRNA Turnover Properties of Late-Exponential and Stationary Phase Staphylococcus aureus Cells
por: Morrison, John M., et al.
Publicado: (2012)

Impact of an Antimicrobial Stewardship Initiative Focused on Staphylococcus aureus Bacteremia
por: Gregory, Eric, et al.
Publicado: (2017)

The osteoblast secretome in Staphylococcus aureus osteomyelitis
por: Granata, Valentina, et al.
Publicado: (2022)

Alu RNP and Alu RNA regulate translation initiation in vitro
por: Häsler, Julien, et al.
Publicado: (2006)

Nuclear RNP complex assembly initiates cytoplasmic RNA localization
por: Kress, Tracy L., et al.
Publicado: (2004)

Genetic Pathway in Acquisition and Loss of Vancomycin Resistance in a Methicillin Resistant Staphylococcus aureus (MRSA) Strain of Clonal Type USA300
por: Gardete, Susana, et al.
Publicado: (2012)

Free-Floating Aggregate and Single-Cell-Initiated Biofilms of Staphylococcus aureus
por: Gupta, Tripti Thapa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_edau8gmjroso7ra4g74q637c1s