Dopamine D(2) Receptor Agonist Binding Kinetics—Role of a Conserved Serine Residue

The forward (k(on)) and reverse (k(off)) rate constants of drug–target interactions have important implications for therapeutic efficacy. Hence, time-resolved assays capable of measuring these binding rate constants may be informative to drug discovery efforts. Here, we used an ion channel activatio...

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Detalles Bibliográficos
Autores principales: Ågren, Richard, Stepniewski, Tomasz Maciej, Zeberg, Hugo, Selent, Jana, Sahlholm, Kristoffer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071183/
https://www.ncbi.nlm.nih.gov/pubmed/33920848
http://dx.doi.org/10.3390/ijms22084078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071183/
https://www.ncbi.nlm.nih.gov/pubmed/33920848
http://dx.doi.org/10.3390/ijms22084078

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