Pharmaceutical Drug Metformin and MCL1 Inhibitor S63845 Exhibit Anticancer Activity in Myeloid Leukemia Cells via Redox Remodeling

Metabolic landscape and sensitivity to apoptosis induction play a crucial role in acute myeloid leukemia (AML) resistance. Therefore, we investigated the effect of metformin, a medication that also acts as an inhibitor of oxidative phosphorylation (OXPHOS), and MCL-1 inhibitor S63845 in AML cell lin...

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Detalles Bibliográficos
Autores principales: Valiulienė, Giedrė, Vitkevičienė, Aida, Skliutė, Giedrė, Borutinskaitė, Veronika, Navakauskienė, Rūta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071510/
https://www.ncbi.nlm.nih.gov/pubmed/33921161
http://dx.doi.org/10.3390/molecules26082303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071510/
https://www.ncbi.nlm.nih.gov/pubmed/33921161
http://dx.doi.org/10.3390/molecules26082303

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