Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells

During X chromosome inactivation (XCI), the inactive X chromosome (Xi) is recruited to the nuclear lamina at the nuclear periphery. Beside X chromosome reactivation resulting in a highly penetrant aging-like hematopoietic malignancy, little is known about XCI in aged hematopoietic stem cells (HSCs)....

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Detalles Bibliográficos
Autores principales: Grigoryan, Ani, Pospiech, Johannes, Krämer, Stephen, Lipka, Daniel, Liehr, Thomas, Geiger, Hartmut, Kimura, Hiroshi, Mulaw, Medhanie A., Florian, Maria Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072063/
https://www.ncbi.nlm.nih.gov/pubmed/33798450
http://dx.doi.org/10.1016/j.stemcr.2021.03.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072063/
https://www.ncbi.nlm.nih.gov/pubmed/33798450
http://dx.doi.org/10.1016/j.stemcr.2021.03.007

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