The Traf2DNxBCL2-tg Mouse Model of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Recapitulates the Biased IGHV Gene Usage, Stereotypy, and Antigen-Specific HCDR3 Selection of Its Human Counterpart

Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL) is a heterogeneous disease consisting of at least two separate subtypes, based on the mutation status of the immunoglobulin heavy chain variable gene (IGHV) sequence. Exposure to antigens seems to play a role in malignant transforma...

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Detalles Bibliográficos
Autores principales: Perez-Chacon, Gema, Zapata, Juan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072112/
https://www.ncbi.nlm.nih.gov/pubmed/33912159
http://dx.doi.org/10.3389/fimmu.2021.627602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072112/
https://www.ncbi.nlm.nih.gov/pubmed/33912159
http://dx.doi.org/10.3389/fimmu.2021.627602

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