5-Bis-(2,6-difluoro-benzylidene) Cyclopentanone Acts as a Selective 11β-Hydroxysteroid Dehydrogenase one Inhibitor to Treat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice

Background: 11β-Hydroxysteroid dehydrogenase one is responsible for activating inert glucocorticoid cortisone into biologically active cortisol in humans and may be a novel target for the treatment of nonalcoholic fatty liver disease. Methods: A series of benzylidene cyclopentanone derivatives were...

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Detalles Bibliográficos
Autores principales: Guan, Hongguo, Wang, Yiyan, Li, Huitao, Zhu, Qiqi, Li, Xiaoheng, Liang, Guang, Ge, Ren-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072159/
https://www.ncbi.nlm.nih.gov/pubmed/33912032
http://dx.doi.org/10.3389/fphar.2021.594437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072159/
https://www.ncbi.nlm.nih.gov/pubmed/33912032
http://dx.doi.org/10.3389/fphar.2021.594437

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