Amiodarone-induced thyroid dysfunction in children: insights from the THYRAMIO study
BACKGROUND: Amiodarone treatment is effective against various types of arrhythmias but is associated with adverse effects affecting, among other organs, thyroid function. Amiodarone-induced thyroid dysfunction was not thoroughly evaluated in children as it was in adults, yet this affection may lead...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072847/ https://www.ncbi.nlm.nih.gov/pubmed/34104391 http://dx.doi.org/10.1177/20420188211001165 |
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author | Montenez, Sarah Moniotte, Stéphane Robert, Annie Desmet, Lieven Lysy, Philippe A. |
author_facet | Montenez, Sarah Moniotte, Stéphane Robert, Annie Desmet, Lieven Lysy, Philippe A. |
author_sort | Montenez, Sarah |
collection | PubMed |
description | BACKGROUND: Amiodarone treatment is effective against various types of arrhythmias but is associated with adverse effects affecting, among other organs, thyroid function. Amiodarone-induced thyroid dysfunction was not thoroughly evaluated in children as it was in adults, yet this affection may lead to irreversible neurodevelopmental complications. Our study aimed to define the incidence and risk factors of amiodarone-induced thyroid dysfunction in children. METHODS: The study was designed as an observational study with a retrospective clinical series of 152 children treated by amiodarone in the Pediatric Cardiology Unit of our center from 1990 to 2019. All patients were divided into three groups according to their thyroid status: euthyroid, AIH (amiodarone-induced hypothyroidism) or AIT (amiodarone-induced thyrotoxicosis). Patients from these three groups were compared in terms of key clinical and therapeutic features. RESULTS: Amiodarone-induced thyroid dysfunction was present in 23% of patients. AIT (5.3%) was three times less common than AIH (17.7%), and its occurrence increased with older age (p < 0.05), treatment dosage (p < 0.05), treatment duration (p < 0.05) and the number of loading doses administered (p < 0.05). There were no distinctive clinical features between euthyroid and AIH groups. A multivariable prediction model of AIT was built, with a yield of 66.7% as positive predictive value and 96.7% as negative predictive value. CONCLUSION: We observed that one in five children developed amiodarone-induced thyroid dysfunction. Special attention is required for older children with a high dosage and long-term therapy and who received a large number of loading doses, since these children are at risk to develop AIT, which is more delicate to manage than AIH. |
format | Online Article Text |
id | pubmed-8072847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-80728472021-06-07 Amiodarone-induced thyroid dysfunction in children: insights from the THYRAMIO study Montenez, Sarah Moniotte, Stéphane Robert, Annie Desmet, Lieven Lysy, Philippe A. Ther Adv Endocrinol Metab Original Research BACKGROUND: Amiodarone treatment is effective against various types of arrhythmias but is associated with adverse effects affecting, among other organs, thyroid function. Amiodarone-induced thyroid dysfunction was not thoroughly evaluated in children as it was in adults, yet this affection may lead to irreversible neurodevelopmental complications. Our study aimed to define the incidence and risk factors of amiodarone-induced thyroid dysfunction in children. METHODS: The study was designed as an observational study with a retrospective clinical series of 152 children treated by amiodarone in the Pediatric Cardiology Unit of our center from 1990 to 2019. All patients were divided into three groups according to their thyroid status: euthyroid, AIH (amiodarone-induced hypothyroidism) or AIT (amiodarone-induced thyrotoxicosis). Patients from these three groups were compared in terms of key clinical and therapeutic features. RESULTS: Amiodarone-induced thyroid dysfunction was present in 23% of patients. AIT (5.3%) was three times less common than AIH (17.7%), and its occurrence increased with older age (p < 0.05), treatment dosage (p < 0.05), treatment duration (p < 0.05) and the number of loading doses administered (p < 0.05). There were no distinctive clinical features between euthyroid and AIH groups. A multivariable prediction model of AIT was built, with a yield of 66.7% as positive predictive value and 96.7% as negative predictive value. CONCLUSION: We observed that one in five children developed amiodarone-induced thyroid dysfunction. Special attention is required for older children with a high dosage and long-term therapy and who received a large number of loading doses, since these children are at risk to develop AIT, which is more delicate to manage than AIH. SAGE Publications 2021-04-24 /pmc/articles/PMC8072847/ /pubmed/34104391 http://dx.doi.org/10.1177/20420188211001165 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Montenez, Sarah Moniotte, Stéphane Robert, Annie Desmet, Lieven Lysy, Philippe A. Amiodarone-induced thyroid dysfunction in children: insights from the THYRAMIO study |
title | Amiodarone-induced thyroid dysfunction in children: insights from the THYRAMIO study |
title_full | Amiodarone-induced thyroid dysfunction in children: insights from the THYRAMIO study |
title_fullStr | Amiodarone-induced thyroid dysfunction in children: insights from the THYRAMIO study |
title_full_unstemmed | Amiodarone-induced thyroid dysfunction in children: insights from the THYRAMIO study |
title_short | Amiodarone-induced thyroid dysfunction in children: insights from the THYRAMIO study |
title_sort | amiodarone-induced thyroid dysfunction in children: insights from the thyramio study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072847/ https://www.ncbi.nlm.nih.gov/pubmed/34104391 http://dx.doi.org/10.1177/20420188211001165 |
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