Temozolomide Induces the Acquisition of Invasive Phenotype by O6-Methylguanine-DNA Methyltransferase (MGMT)(+) Glioblastoma Cells in a Snail-1/Cx43-Dependent Manner

Glioblastoma multiforme (GBM) recurrences after temozolomide (TMZ) treatment result from the expansion of drug-resistant and potentially invasive GBM cells. This process is facilitated by O6-Methylguanine-DNA Methyltransferase (MGMT), which counteracts alkylating TMZ activity. We traced the expansio...

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Detalles Bibliográficos
Autores principales: Kochanowski, Paweł, Catapano, Jessica, Pudełek, Maciej, Wróbel, Tomasz, Madeja, Zbigniew, Ryszawy, Damian, Czyż, Jarosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073161/
https://www.ncbi.nlm.nih.gov/pubmed/33923767
http://dx.doi.org/10.3390/ijms22084150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073161/
https://www.ncbi.nlm.nih.gov/pubmed/33923767
http://dx.doi.org/10.3390/ijms22084150

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