PCSK9 Induces Rat Smooth Muscle Cell Proliferation and Counteracts the Pleiotropic Effects of Simvastatin

Human atherosclerotic plaque contains smooth muscle cells (SMCs) negative for the contractile phenotype (α-smooth muscle actin) but positive for proprotein convertase subtilisin/kexin type 9 (PCSK9). Thus, we generated rat SMCs which overexpressed human PCSK9 (SMCs(PCSK9)) with the aim of investigat...

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Detalles Bibliográficos
Autores principales: Lupo, Maria Giovanna, Marchianò, Silvia, Adorni, Maria Pia, Zimetti, Francesca, Ruscica, Massimiliano, Greco, Maria Francesca, Corsini, Alberto, Ferri, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073479/
https://www.ncbi.nlm.nih.gov/pubmed/33923431
http://dx.doi.org/10.3390/ijms22084114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073479/
https://www.ncbi.nlm.nih.gov/pubmed/33923431
http://dx.doi.org/10.3390/ijms22084114

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