Cargando…

Human Prostate Epithelial Cells Activate the AIM2 Inflammasome upon Cellular Senescence: Role of POP3 Protein in Aging-Related Prostatic Inflammation

Increased levels of type I (T1) interferon (IFN)-inducible POP3 protein in myeloid cells inhibit activation of the AIM2 inflammasome and production of IL-1β and IL-18 proinflammatory cytokines. The AIM2 mRNA levels were significantly higher in benign prostate hyperplasia (BPH) than the normal prosta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Panchanathan, Ravichandran, Ramalingam, Vaikundamoorthy, Liu, Hongzhu, Choubey, Divaker
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073538/ https://www.ncbi.nlm.nih.gov/pubmed/33923931 http://dx.doi.org/10.3390/life11040366

Ejemplares similares

Hypoxia primes human normal prostate epithelial cells and cancer cell lines for the NLRP3 and AIM2 inflammasome activation
por: Panchanathan, Ravichandran, et al.
Publicado: (2016)

IFI16 Protein Mediates the Anti-inflammatory Actions of the Type-I Interferons through Suppression of Activation of Caspase-1 by Inflammasomes
por: Veeranki, Sudhakar, et al.
Publicado: (2011)

Mutually Positive Regulatory Feedback Loop between Interferons and Estrogen Receptor-α in Mice: Implications for Sex Bias in Autoimmunity
por: Panchanathan, Ravichandran, et al.
Publicado: (2010)

Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease
por: Choubey, Divaker
Publicado: (2019)

From Inflammation to Prostate Cancer: The Role of Inflammasomes
por: Karan, Dev, et al.
Publicado: (2016)

Inflammasomes are important mediators of prostatic inflammation associated with BPH
por: Kashyap, Mahendra, et al.
Publicado: (2015)

The PYRIN domain-only protein POP3 inhibits AIM2-like receptor inflammasomes and regulates responses to DNA virus infections
por: Khare, Sonal, et al.
Publicado: (2014)

Stimulation of prostate cells by the senescence phenotype of epithelial and stromal cells: Implication for benign prostate hyperplasia
por: Jiang, Shoulei, et al.
Publicado: (2019)

Mitochondrial Dysfunction and Cellular Senescence Due to Aging Contributes to Prostatic Fibrosis
por: Liu, Teresa, et al.
Publicado: (2020)

Distinct mechanisms mediating therapy-induced cellular senescence in prostate cancer
por: Kallenbach, Julia, et al.
Publicado: (2022)

Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome
por: Green, Jack P., et al.
Publicado: (2023)

Inflammasome-independent functions of AIM2
por: Zhao, Junjie, et al.
Publicado: (2021)

POP1 inhibits MSU-induced inflammasome activation and ameliorates gout
por: de Almeida, Lucia, et al.
Publicado: (2022)

You prime what you code: The fAIM model of priming of pop-out
por: Kruijne, Wouter, et al.
Publicado: (2017)

Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer
por: Kokal, Miriam, et al.
Publicado: (2020)

IFI16 Induction by Glucose Restriction in Human Fibroblasts Contributes to Autophagy through Activation of the ATM/AMPK/p53 Pathway
por: Duan, Xin, et al.
Publicado: (2011)

Cellular Senescence in the Lung: The Central Role of Senescent Epithelial Cells
por: Hansel, Christine, et al.
Publicado: (2020)

Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis
por: Wang, Jieyi, et al.
Publicado: (2022)

Target delivery of doxorubicin tethered with PVP stabilized gold nanoparticles for effective treatment of lung cancer
por: Ramalingam, Vaikundamoorthy, et al.
Publicado: (2018)

The Role of AIM2 Inflammasome in Knee Osteoarthritis
por: Yang, Jiyong, et al.
Publicado: (2022)

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
por: Ratsimandresy, Rojo A., et al.
Publicado: (2017)

Epithelial Cell Inflammasomes in Intestinal Immunity and Inflammation
por: Lei-Leston, Andrea C., et al.
Publicado: (2017)

Recent evolution of the NF-κB and inflammasome regulating protein POP2 in primates
por: Atianand, Maninjay K, et al.
Publicado: (2011)

An Update on CARD Only Proteins (COPs) and PYD Only Proteins (POPs) as Inflammasome Regulators
por: Devi, Savita, et al.
Publicado: (2020)

Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer
por: Karan, Dev, et al.
Publicado: (2017)

A gene prognostic index from cellular senescence predicting metastasis and radioresistance for prostate cancer
por: Feng, Dechao, et al.
Publicado: (2022)

DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis
por: Cho, Soo Jung, et al.
Publicado: (2019)

Structural Characterization, Antimicrobial, Antibiofilm, Antioxidant, Anticancer and Acute Toxicity Properties of N-(2-hydroxyphenyl)-2-phenazinamine From Nocardiopsis exhalans (KP149558)
por: Ramalingam, Vaikundamoorthy, et al.
Publicado: (2022)

Prostate Biopsy Sampling Causes Hematogenous Dissemination of Epithelial Cellular Material
por: Ladjevardi, Sam, et al.
Publicado: (2014)

Cellular Senescence, Inflammation, and Cancer in the Gastrointestinal Tract
por: Choi, Egan L., et al.
Publicado: (2023)

Biliary Epithelial Senescence and Plasticity in Acute Cellular Rejection
por: Brain, J G, et al.
Publicado: (2013)

Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome
por: Crane, Deborah D., et al.
Publicado: (2014)

Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes
por: Sharma, Meenakshi, et al.
Publicado: (2021)

Regulatory Cues in Pulmonary Fibrosis—With Emphasis on the AIM2 Inflammasome
por: Tseng, Yu-Hsin, et al.
Publicado: (2023)

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis
por: Gao, Jian, et al.
Publicado: (2019)

Inflammation induced by lipopolysaccharide advanced androgen receptor expression and epithelial-mesenchymal transition progress in prostatitis and prostate cancer
por: Wang, Guang-Chun, et al.
Publicado: (2021)

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence
por: Fernández-Duran, Irene, et al.
Publicado: (2021)

Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome
por: Huang, Yuan, et al.
Publicado: (2017)

Cytotoxic Action of Palladium-Based Compound on Prostate Stem Cells, Primary Prostate Epithelial Cells, Prostate Epithelial Cells, and Prostate Cell Lines
por: Cheng, Long, et al.
Publicado: (2022)

Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal
por: Kuehnemann, Chisaka, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fcgeudnb8k8dtk4tevhkbq2pel