Design, Synthesis, Biological Evaluation and In Silico Studies of Pyrazole-Based NH(2)-Acyl Oseltamivir Analogues as Potent Neuraminidase Inhibitors

Oseltamivir represents one of the most successful neuraminidase (NA) inhibitors in the current anti-influenza therapy. The 150-cavity of NA was identified as an additional binding pocket, and novel NA inhibitors have been designed to occupy the 150-cavity based on the structure information of oselta...

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Detalles Bibliográficos
Autores principales: Ye, Jiqing, Lin, Lin, Xu, Jinyi, Chan, Paul Kay-sheung, Yang, Xiao, Ma, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073777/
https://www.ncbi.nlm.nih.gov/pubmed/33923858
http://dx.doi.org/10.3390/ph14040371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073777/
https://www.ncbi.nlm.nih.gov/pubmed/33923858
http://dx.doi.org/10.3390/ph14040371

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