Cargando…

Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells

The orphan nuclear receptor 4A1 (NR4A1) is overexpressed in pancreatic cancer and exhibits pro-oncogenic activity, and NR4A1 silencing and treatment with its inactivators has been shown to inhibit pancreatic cancer cells and tumor growth. In this study, we identified broussochalcone A (BCA) as a new...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Hyo-Seon, Kim, Soo-Hyun, Kim, Bo-Mi, Safe, Stephen, Lee, Syng-Ook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073833/ https://www.ncbi.nlm.nih.gov/pubmed/33923503 http://dx.doi.org/10.3390/molecules26082316

Ejemplares similares

Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1)
por: Lee, Miok, et al.
Publicado: (2023)

Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma
por: Hedrick, Erik, et al.
Publicado: (2015)

Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth
por: Shrestha, Rupesh, et al.
Publicado: (2021)

Piperlongumine is a ligand for the orphan nuclear receptor 4A1 (NR4A1)
por: Zhang, Lei, et al.
Publicado: (2023)

Broussochalcone A Induces Apoptosis in Human Renal Cancer Cells via ROS Level Elevation and Activation of FOXO3 Signaling Pathway
por: Lee, Han Ki, et al.
Publicado: (2021)

Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo
por: Lee, Hyo-Seon, et al.
Publicado: (2022)

In Silico Adoption of an Orphan Nuclear Receptor NR4A1
por: Lanig, Harald, et al.
Publicado: (2015)

The Nuclear Receptor TR3 Regulates mTORC1 Signaling in Lung Cancer Cells Expressing Wild-type p53
por: Lee, Syng-Ook, et al.
Publicado: (2011)

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues
por: Herring, Jacob A., et al.
Publicado: (2019)

The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis
por: Yu, Cong, et al.
Publicado: (2015)

Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology
por: Odagiu, Livia, et al.
Publicado: (2021)

Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes
por: Zhang, Chenyang, et al.
Publicado: (2020)

The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis
por: Jin, Un-Ho, et al.
Publicado: (2014)

The Nuclear Orphan Receptor NR4A1 is Involved in the Apoptotic Pathway Induced by LPS and Simvastatin in RAW 264.7 Macrophages
por: Kim, Yong Chan, et al.
Publicado: (2014)

The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) Is Druggable
por: Benod, Cindy, et al.
Publicado: (2014)

Co-activator candidate interactions for orphan nuclear receptor NR2E1
por: Corso-Díaz, Ximena, et al.
Publicado: (2016)

Aspirin Inhibits Colon Cancer Cell and Tumor Growth and Downregulates Specificity Protein (Sp) Transcription Factors
por: Pathi, Satya, et al.
Publicado: (2012)

Oncogenic Orphan Nuclear Receptor NR4A3 Interacts and Cooperates with MYB in Acinic Cell Carcinoma
por: Lee, David Y., et al.
Publicado: (2020)

Chemoprevention of Skin Cancer with 1,1-Bis (3′-Indolyl)-1-(Aromatic) Methane Analog through Induction of the Orphan Nuclear Receptor, NR4A2 (Nurr1)
por: Boakye, Cedar H. A., et al.
Publicado: (2013)

Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin
por: McCoy, Joseph M, et al.
Publicado: (2015)

The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance
por: Hermann-Kleiter, Natascha, et al.
Publicado: (2015)

The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions
por: Seitz, Carina, et al.
Publicado: (2019)

Nuclear orphan receptor NR2F6 as a safeguard against experimental murine colitis
por: Klepsch, Victoria, et al.
Publicado: (2018)

Relevance of the NR4A sub-family of nuclear orphan receptors in trophoblastic BeWo cell differentiation
por: Malhotra, Sudha Saryu, et al.
Publicado: (2017)

Disruption of Beta-Cell Mitochondrial Networks by the Orphan Nuclear Receptor Nor1/Nr4a3
por: Close, Anne-Françoise, et al.
Publicado: (2020)

Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer
por: Park, Yun-Yong, et al.
Publicado: (2012)

The orphan nuclear receptor NR4A2 is part of a p53–microRNA-34 network
por: Beard, Jordan A., et al.
Publicado: (2016)

The orphan nuclear receptor Nr4a1 mediates perinatal neuroinflammation in a murine model of preterm labor
por: Estrada, Sarah M., et al.
Publicado: (2020)

Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma
por: Zarei, Mehrdad, et al.
Publicado: (2021)

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4(+) T cells
por: Sekiya, Takashi, et al.
Publicado: (2011)

Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein
por: Olejnik-Schmidt, Agnieszka K., et al.
Publicado: (2006)

Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy
por: Klepsch, Victoria, et al.
Publicado: (2020)

Emerging Next-Generation Target for Cancer Immunotherapy Research: The Orphan Nuclear Receptor NR2F6
por: Klepsch, Victoria, et al.
Publicado: (2021)

Correction: The orphan nuclear receptor Nr4a1 mediates perinatal neuroinflammation in a murine model of preterm labor
por: Estrada, Sarah M., et al.
Publicado: (2020)

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ
por: Park, Yun-Yong, et al.
Publicado: (2005)

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ
por: Park, Yun-Yong, et al.
Publicado: (2018)

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ
por: Park, Yun-Yong, et al.
Publicado: (2019)

NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth
por: Karki, Keshav, et al.
Publicado: (2021)

The Orphan Nuclear Receptor Liver Homolog Receptor-1 (Nr5a2) Regulates Ovarian Granulosa Cell Proliferation
por: Meinsohn, Marie-Charlotte, et al.
Publicado: (2017)

MiR-506 Suppresses Colorectal Cancer Development by Inhibiting Orphan Nuclear Receptor NR4A1 Expression
por: Huang, Meihui, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6h58m47t6lfq4kek0usnmoslr4