Cyclin-Dependent Kinase Inhibitor BMI-1026 Induces Apoptosis by Downregulating Mcl-1 (L) and c-FLIP (L) and Inactivating p-Akt in Human Renal Carcinoma Cells

Previous studies have investigated the inhibitory effect of BMI-1026 on cyclin-dependent kinase 1 in vitro. However, the molecular mechanisms by which BMI-1026 treatment leads to cancer cell death remain unclear. This study was conducted to investigate the anticancer mechanisms of BMI-1026 on human...

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Detalles Bibliográficos
Autores principales: Kim, Dong Eun, Lee, Jinho, Park, Jong Wook, Kang, Hyunsu, Nam, Yu Ri, Kwon, Taeg Kyu, Kim, Ki-Suk, Kim, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073842/
https://www.ncbi.nlm.nih.gov/pubmed/33924053
http://dx.doi.org/10.3390/ijms22084268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073842/
https://www.ncbi.nlm.nih.gov/pubmed/33924053
http://dx.doi.org/10.3390/ijms22084268

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