A Metal-Free, Disulfide Oxidized Form of Superoxide Dismutase 1 as a Primary Misfolded Species with Prion-Like Properties in the Extracellular Environments Surrounding Motor Neuron-Like Cells

Superoxide dismutase 1 (SOD1) is a metalloenzyme with high structural stability, but a lack of Cu and Zn ions decreases its stability and enhances the likelihood of misfolding, which is a pathological hallmark of amyotrophic lateral sclerosis (ALS). A growing body of evidence has demonstrated that m...

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Detalles Bibliográficos
Autores principales: Takashima, Chika, Kosuge, Yasuhiro, Inoue, Masahisa, Ono, Shin-Ichi, Tokuda, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074096/
https://www.ncbi.nlm.nih.gov/pubmed/33923808
http://dx.doi.org/10.3390/ijms22084155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074096/
https://www.ncbi.nlm.nih.gov/pubmed/33923808
http://dx.doi.org/10.3390/ijms22084155

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