Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro- and Anti-Apoptotic Factors in an Animal Model of Epilepsy

We aimed to characterize the mechanisms involved in neuroprotection by R-PIA administered before pilocarpine-induced seizures. Caspase-1 and caspase-3 activities were assayed using fluorimetry, and cathepsin D, HSP-70, and AKT expression levels were assayed using Western Blot of hippocampal samples....

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Detalles Bibliográficos
Autores principales: Persike, Daniele Suzete, Puccinelli, Rebeca Padrão Amorim, Fernandes, Maria José da Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074097/
https://www.ncbi.nlm.nih.gov/pubmed/33919533
http://dx.doi.org/10.3390/ph14040376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074097/
https://www.ncbi.nlm.nih.gov/pubmed/33919533
http://dx.doi.org/10.3390/ph14040376

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