Relationship between Oxidative Stress and Imatinib Resistance in Model Chronic Myeloid Leukemia Cells

Chronic myeloid leukemia (CML) develops due to the presence of the BCR-ABL1 protein, a target of tyrosine kinase inhibitors (TKIs), such as imatinib (IM), used in a CML therapy. CML eradication is a challenge due to developing resistance to TKIs. BCR-ABL1 induces endogenous oxidative stress leading...

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Detalles Bibliográficos
Autores principales: Głowacki, Sylwester, Synowiec, Ewelina, Szwed, Marzena, Toma, Monika, Skorski, Tomasz, Śliwiński, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074285/
https://www.ncbi.nlm.nih.gov/pubmed/33924068
http://dx.doi.org/10.3390/biom11040610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074285/
https://www.ncbi.nlm.nih.gov/pubmed/33924068
http://dx.doi.org/10.3390/biom11040610

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