Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells

Pepsin refluxate is considered a risk factor for laryngopharyngeal carcinogenesis. Non-acidic pepsin was previously linked to an inflammatory and tumorigenic effect on laryngopharyngeal cells in vitro. Yet there is no clear evidence of the pepsin-effect on a specific oncogenic pathway and the import...

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Detalles Bibliográficos
Autores principales: Doukas, Panagiotis G., Vageli, Dimitra P., Sasaki, Clarence T., Judson, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074291/
https://www.ncbi.nlm.nih.gov/pubmed/33924087
http://dx.doi.org/10.3390/ijms22084275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074291/
https://www.ncbi.nlm.nih.gov/pubmed/33924087
http://dx.doi.org/10.3390/ijms22084275

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