MicroRNA-199a-5p accelerates nucleus pulposus cell apoptosis and IVDD by inhibiting SIRT1-mediated deacetylation of p21

Intervertebral disc degeneration (IVDD) is a multifactorial pathological process associated with low back pain in which nucleus pulposus cell senescence is disrupted. Increasing evidence reveals that IVDD can be modulated by microRNAs (miRNAs or miRs). In the current study, we set out to elucidate t...

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Detalles Bibliográficos
Autores principales: Sun, Yiqiang, Wang, Xia, Fu, Guoyong, Geng, Xiaopeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076653/
https://www.ncbi.nlm.nih.gov/pubmed/33981481
http://dx.doi.org/10.1016/j.omtn.2021.02.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076653/
https://www.ncbi.nlm.nih.gov/pubmed/33981481
http://dx.doi.org/10.1016/j.omtn.2021.02.009

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