RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression

BACKGROUND: Type 2 diabetes (T2D) is a common metabolic disease. Variants in human IGF2 mRNA binding protein 2 (IMP2/IGF2BP2) are associated with increased risk of T2D. IMP2 contributes to T2D susceptibility primarily through effects on insulin secretion. However, the underlying mechanism is not kno...

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Detalles Bibliográficos
Autores principales: Regué, Laura, Zhao, Liping, Ji, Fei, Wang, Hua, Avruch, Joseph, Dai, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076713/
https://www.ncbi.nlm.nih.gov/pubmed/33705986
http://dx.doi.org/10.1016/j.molmet.2021.101209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076713/
https://www.ncbi.nlm.nih.gov/pubmed/33705986
http://dx.doi.org/10.1016/j.molmet.2021.101209

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