Cargando…

Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin

Mutations in the cardiac myosin regulatory light chain (RLC, MYL2 gene) are known to cause inherited cardiomyopathies with variable phenotypes. In this study, we investigated the impact of a mutation in the RLC (K104E) that is associated with hypertrophic cardiomyopathy (HCM). Previously in a mouse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rasicci, David V., Kirkland, Orville, Moonschi, Faruk H., Wood, Neil B., Szczesna-Cordary, Danuta, Previs, Michael J., Wenk, Jonathan F., Campbell, Kenneth S., Yengo, Christopher M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077168/ https://www.ncbi.nlm.nih.gov/pubmed/33891674 http://dx.doi.org/10.1085/jgp.202012811

Ejemplares similares

Single cardiac ventricular myosins are autonomous motors
por: Wang, Yihua, et al.
Publicado: (2018)

Functional comparison of phosphomimetic S15D and T160D mutants of myosin regulatory light chain exchanged in cardiac muscle preparations of HCM and WT mice
por: Kazmierczak, Katarzyna, et al.
Publicado: (2022)

Phosphorylation Mimetic of Myosin Regulatory Light Chain Mitigates Cardiomyopathy-Induced Myofilament Impairment in Mouse Models of RCM and DCM
por: Kazmierczak, Katarzyna, et al.
Publicado: (2023)

Remodeling of the heart in hypertrophy in animal models with myosin essential light chain mutations
por: Kazmierczak, Katarzyna, et al.
Publicado: (2014)

Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin
por: Sitbon, Yoel H., et al.
Publicado: (2021)

The effect of myosin RLC phosphorylation in normal and cardiomyopathic mouse hearts
por: Muthu, Priya, et al.
Publicado: (2012)

Nanosurfer assay dissects β-cardiac myosin and cardiac myosin-binding protein C interactions
por: Touma, Anja M., et al.
Publicado: (2022)

Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice
por: Yuan, Chen-Ching, et al.
Publicado: (2018)

Molecular basis of force-pCa relation in MYL2 cardiomyopathy mice: Role of the super-relaxed state of myosin
por: Yuan, Chen-Ching, et al.
Publicado: (2022)

Coupling of ATPase activity and motility in smooth muscle myosin is mediated by the regulatory light chain
Publicado: (1994)

Molecular Mechanism of Muscle Contraction: New Perspectives and Ideas
por: Matusovsky, Oleg S., et al.
Publicado: (2015)

Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin
por: Rasicci, David V, et al.
Publicado: (2022)

Molecular and Functional Effects of a Splice Site Mutation in the MYL2 Gene Associated with Cardioskeletal Myopathy and Early Cardiac Death in Infants
por: Zhou, Zhiqun, et al.
Publicado: (2016)

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I
por: Sevrieva, Ivanka R., et al.
Publicado: (2020)

Does Interaction between the Motor and Regulatory Domains of the Myosin Head Occur during ATPase Cycle? Evidence from Thermal Unfolding Studies on Myosin Subfragment 1
por: Logvinova, Daria S., et al.
Publicado: (2015)

Suramin Inhibits Hsp104 ATPase and Disaggregase Activity
por: Torrente, Mariana P., et al.
Publicado: (2014)

Cardiomyopathies: Classification, Clinical Characterization, and Functional Phenotypes
por: Szczesna-Cordary, Danuta, et al.
Publicado: (2012)

Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits
por: Dash, Bhagirathi, et al.
Publicado: (2018)

The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle
por: Kampourakis, Thomas, et al.
Publicado: (2021)

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation
por: Doran, Matthew H., et al.
Publicado: (2022)

The R21C Mutation in Cardiac Troponin I Imposes Differences in Contractile Force Generation between the Left and Right Ventricles of Knock-In Mice
por: Liang, Jingsheng, et al.
Publicado: (2015)

The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness
por: Jiang, Fangfang, et al.
Publicado: (2021)

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin
por: Doran, Matthew H., et al.
Publicado: (2023)

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle
por: Kampourakis, Thomas, et al.
Publicado: (2015)

Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding
por: Inchingolo, Alessio V., et al.
Publicado: (2019)

Cardiac Myosin Filaments are Maintained by Stochastic Protein Replacement
por: Wood, Neil B., et al.
Publicado: (2022)

Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle
por: Nelson, Shane, et al.
Publicado: (2023)

Biochemical kinetic characterization of the Acanthamoeba myosin-I ATPase
Publicado: (1996)

ATPase Activity of Myosin Correlated with Speed of Muscle Shortening
por: Bárány, Michael
Publicado: (1967)

Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives
por: Yu, Haiyang, et al.
Publicado: (2016)

Hydroxychloroquine Mitigates Dilated Cardiomyopathy Phenotype in Transgenic D94A Mice
por: Kanashiro-Takeuchi, Rosemeire M., et al.
Publicado: (2022)

Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine Cancer
por: Richter, Camden, et al.
Publicado: (2020)

The role of the myosin ATPase activity in adaptive thermogenesis by skeletal muscle
por: Cooke, Roger
Publicado: (2011)

Myocyte contractility can be maintained by storing cells with the myosin ATPase inhibitor 2,3 butanedione monoxime
por: Chung, Charles S, et al.
Publicado: (2015)

Motor Mechanism for Protein Threading through Hsp104
por: Wendler, Petra, et al.
Publicado: (2009)

Rho Kinase's Role in Myosin Recruitment to the Equatorial Cortex of Mitotic Drosophila S2 Cells Is for Myosin Regulatory Light Chain Phosphorylation
por: Dean, Sara O., et al.
Publicado: (2006)

Myosin light chain phosphatase catalytic subunit dephosphorylates cardiac myosin via mechanisms dependent and independent of the MYPT regulatory subunits
por: Lee, Eunyoung, et al.
Publicado: (2022)

Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels
por: Tang, Wanjian, et al.
Publicado: (2017)

Slit and Netrin-1 guide cranial motor axon pathfinding via Rho-kinase, myosin light chain kinase and myosin II
por: Murray, Ailish, et al.
Publicado: (2010)

A Small-Molecule Inhibitor of T. gondii Motility Induces the Posttranslational Modification of Myosin Light Chain-1 and Inhibits Myosin Motor Activity
por: Heaslip, Aoife T., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_qtnovjvqvu2rc9eh00h4b996c9