Cargando…

Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regions

The comorbid association of autoimmune diseases with cancers has been a major obstacle to successful anti-cancer treatment. Cancer survival rate decreases significantly in patients with preexisting autoimmunity. However, to date, the molecular and cellular profiles of such comorbidities are poorly u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Kiwon, Ryoo, Jeongmin, Jeong, Heena, Kim, Minsu, Lee, Sungwon, Hwang, Sung-Yeon, Ahn, Jiyoung, Kim, Doyeon, Moon, Hyungseok C., Baek, Daehyun, Kim, Kwangsoo, Park, Hye Yoon, Ahn, Kwangseog
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078737/ https://www.ncbi.nlm.nih.gov/pubmed/33857133 http://dx.doi.org/10.1371/journal.pgen.1009523

Ejemplares similares

A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature
por: Oh, Changhoon, et al.
Publicado: (2018)

Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1
por: Zhao, Ke, et al.
Publicado: (2013)

Aicardi–Goutières syndrome with SAMHD1 deficiency can be diagnosed by unscheduled DNA synthesis test
por: Senju, Chikako, et al.
Publicado: (2022)

Elimination of Aicardi–Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication
por: Oo, Adrian, et al.
Publicado: (2022)

SAMHD1 specifically restricts retroviruses through its RNase activity
por: Choi, Jongsu, et al.
Publicado: (2015)

Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi–Goutières syndrome SAMHD1 dNTPase ortholog
por: Maehigashi, Tatsuya, et al.
Publicado: (2023)

Characterization of a mutant samhd1 zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome
por: Withers, Sarah E., et al.
Publicado: (2023)

MRI Features Predictive of Aicardi-Goutieres Syndrome
por: Millichap, J. Gordon
Publicado: (2015)

Aicardi–Goutières Syndrome: Brief Case Report
por: Moscote-Salazar, Luis Rafael, et al.
Publicado: (2018)

3358 Developmental Outcomes of Aicardi Goutieres Syndrome
por: Adang, Laura, et al.
Publicado: (2019)

SAMHD1-Deficient CD14+ Cells from Individuals with Aicardi-Goutières Syndrome Are Highly Susceptible to HIV-1 Infection
por: Berger, André, et al.
Publicado: (2011)

Interferon-α and the calcifying microangiopathy in Aicardi–Goutières syndrome
por: Klok, Melanie D, et al.
Publicado: (2015)

Family History of Autoimmune Disease in Patients with Aicardi-Goutières Syndrome
por: Schmidt, Johanna L., et al.
Publicado: (2012)

Endocrinopathies in Aicardi Goutières syndrome—A descriptive case series
por: Worth, Chris, et al.
Publicado: (2020)

Analysis of clinical characteristics of children with Aicardi-Goutieres syndrome in China
por: Wang, Wei, et al.
Publicado: (2022)

Relapsing–remitting clinical course expands the phenotype of Aicardi–Goutières syndrome
por: Lambe, Jeffrey, et al.
Publicado: (2020)

Interstitial Lung Disease and Psoriasis in a Child With Aicardi-Goutières Syndrome
por: Zheng, Shaoling, et al.
Publicado: (2020)

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes
por: Giordano, Anna Maria Sole, et al.
Publicado: (2022)

Incidence of Aicardi-Goutières syndrome and KCNT1-related epilepsy in Denmark
por: Møller, Rikke S., et al.
Publicado: (2022)

Subacute Partially Reversible Leukoencephalopathy Expands the Aicardi–Goutières Syndrome Phenotype
por: Peixoto de Barcelos, Isabella, et al.
Publicado: (2023)

Cerebral Arterial Stenoses and Stroke: Novel Features of Aicardi-Goutières Syndrome Caused by the Arg164X Mutation in SAMHD1 Are Associated with Altered Cytokine Expression
por: Thiele, Holger, et al.
Publicado: (2010)

Recurrent Encephalopathy with Spinal Cord Involvement: An Atypical Manifestation of Aicardi–Goutières Syndrome
por: Samanta, Debopam, et al.
Publicado: (2019)

Aicardi-Goutières syndrome due to a paternal mosaic IFIH1 mutation
por: Tüngler, Victoria, et al.
Publicado: (2019)

Genetic Testing Contributes to Diagnosis in Cerebral Palsy: Aicardi-Goutières Syndrome as an Example
por: Beysen, Diane, et al.
Publicado: (2021)

Case Report: Aicardi-Goutières Syndrome Caused by Novel TREX1 Variants
por: Wu, De, et al.
Publicado: (2021)

Inflammatory cytokine production in a mouse model of Aicardi-Goutieres syndrome and neuroinflammation
por: Wiley, Clayton A., et al.
Publicado: (2022)

A case of Aicardi-Goutières syndrome caused by TREX1 gene mutation
por: Chenhan, Zheng, et al.
Publicado: (2023)

Aicardi–Goutières Syndrome with Congenital Glaucoma Caused by Novel TREX1 Mutation
por: Świerczyńska, Marta, et al.
Publicado: (2023)

Comparison between D-loop methylation and mtDNA copy number in patients with Aicardi-Goutières Syndrome
por: Dragoni, Francesca, et al.
Publicado: (2023)

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome
por: Lim, Yoong Wearn, et al.
Publicado: (2015)

RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition
por: Benitez‐Guijarro, Maria, et al.
Publicado: (2018)

Cutaneous Lesions as a Clue to the Etiology of Extensive Intracranial Calcifications: Aicardi-Goutières Syndrome
por: Zeng, Yi-Heng, et al.
Publicado: (2022)

SARS-CoV-2 mRNA-based vaccines in the Aicardi Goutières Syndrome
por: Takanohashi, Asako, et al.
Publicado: (2022)

Aicardi-Goutières syndrome type 7 in a Chinese child: A case report
por: Lin, Shuang-Zhu, et al.
Publicado: (2023)

Clinical spectrum and currently available treatment of type I interferonopathy Aicardi–Goutières syndrome
por: Dell’Isola, Giovanni Battista, et al.
Publicado: (2023)

Treatment response to Janus kinase inhibitor in a child affected by Aicardi‐Goutières syndrome
por: Galli, Jessica, et al.
Publicado: (2023)

Efficacy of Baricitinib in the Treatment of Chilblains Associated With Aicardi‐Goutières Syndrome, a Type I Interferonopathy
por: Meesilpavikkai, Kornvalee, et al.
Publicado: (2019)

JAK Inhibition in Aicardi-Goutières Syndrome: a Monocentric Multidisciplinary Real-World Approach Study
por: Frémond, Marie-Louise, et al.
Publicado: (2023)

Unusual Association of Aniridia with Aicardi-Goutières Syndrome-Related Congenital Glaucoma in a Tertiary Care Center
por: Musalem, Hebah M., et al.
Publicado: (2018)

Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer
por: Deasy, Sarah K., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_aqdi5sfjnroj1vgboqevrvp4lq