Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers

Novel tolmetin derivatives 5a–f to 8a–c were designed, synthesised, and evaluated for antiproliferative activity by NCI (USA) against a panel of 60 tumour cell lines. The cytotoxic activity of the most active tolmetin derivatives 5b and 5c was examined against HL-60, HCT-15, and UO-31 tumour cell li...

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Detalles Bibliográficos
Autores principales: Kassab, Asmaa E., Gedawy, Ehab M., Hamed, Mohammed I. A., Doghish, Ahmed S., Hassan, Rasha A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079033/
https://www.ncbi.nlm.nih.gov/pubmed/33896327
http://dx.doi.org/10.1080/14756366.2021.1901089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079033/
https://www.ncbi.nlm.nih.gov/pubmed/33896327
http://dx.doi.org/10.1080/14756366.2021.1901089

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