Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agents

Compounds combining dual inhibitory action against FAAH and cyclooxygenase (COX) may be potentially useful analgesics. Here, we describe a novel flurbiprofen analogue, N-(3-bromopyridin-2-yl)-2-(2-fluoro-(1,1'-biphenyl)-4-yl)propanamide (Flu-AM4). The compound is a competitive, reversible inhib...

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Detalles Bibliográficos
Autores principales: Deplano, Alessandro, Karlsson, Jessica, Moraca, Federica, Svensson, Mona, Cristiano, Claudia, Morgillo, Carmine Marco, Fowler, Christopher J., Russo, Roberto, Catalanotti, Bruno, Onnis, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079065/
https://www.ncbi.nlm.nih.gov/pubmed/33896320
http://dx.doi.org/10.1080/14756366.2021.1875459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079065/
https://www.ncbi.nlm.nih.gov/pubmed/33896320
http://dx.doi.org/10.1080/14756366.2021.1875459

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