BEZ235 Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Inhibiting PI3K/AKT/mTOR and Inducing Autophagy

Acquired resistance of hepatocellular carcinoma (HCC) to sorafenib (SFB) is the main reason for the failure of SFB treatment of the cancer. Abnormal activation of the PI3K/AKT/mTOR pathway is important in the acquired resistance of SFB. Therefore, we investigated whether BEZ235 (BEZ) could reverse a...

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Detalles Bibliográficos
Autores principales: Cao, Weiya, Liu, Xueke, Zhang, Yinci, Li, Amin, Xie, Yinghai, Zhou, Shuping, Song, Li, Xu, Ruyue, Ma, Yongfang, Cai, Shiyu, Tang, Xiaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079203/
https://www.ncbi.nlm.nih.gov/pubmed/33987439
http://dx.doi.org/10.1155/2021/5556306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079203/
https://www.ncbi.nlm.nih.gov/pubmed/33987439
http://dx.doi.org/10.1155/2021/5556306

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