ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells

ALK inhibitors effectively target EML4-ALK positive non-small cell lung cancer, but their effects are hampered by treatment resistance. In the present study, we asked whether ALK inhibition affects autophagy, and whether this may influence treatment response. Whereas the impact of targeted therapies...

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Detalles Bibliográficos
Autores principales: Schläfli, Anna M., Tokarchuk, Igor, Parejo, Sarah, Jutzi, Susanne, Berezowska, Sabina, Engedal, Nikolai, Tschan, Mario P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079437/
https://www.ncbi.nlm.nih.gov/pubmed/33907223
http://dx.doi.org/10.1038/s41598-021-87966-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079437/
https://www.ncbi.nlm.nih.gov/pubmed/33907223
http://dx.doi.org/10.1038/s41598-021-87966-6

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