The heat shock response, determined by QuantiGene multiplex, is impaired in HD mouse models and not caused by HSF1 reduction

Huntington’s disease (HD) is a devastating neurodegenerative disorder, caused by a CAG/polyglutamine repeat expansion, that results in the aggregation of the huntingtin protein, culminating in the deposition of inclusion bodies in HD patient brains. We have previously shown that the heat shock respo...

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Detalles Bibliográficos
Autores principales: Gomez-Paredes, Casandra, Mason, Michael A., Taxy, Bridget A., Papadopoulou, Aikaterini S., Paganetti, Paolo, Bates, Gillian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079691/
https://www.ncbi.nlm.nih.gov/pubmed/33907289
http://dx.doi.org/10.1038/s41598-021-88715-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079691/
https://www.ncbi.nlm.nih.gov/pubmed/33907289
http://dx.doi.org/10.1038/s41598-021-88715-5

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