Large-Volume Intrathecal Administrations: Impact on CSF Pressure and Safety Implications

The increasing number of studies demonstrates the high potency of the intrathecal (IT) route for the delivery of biopharmaceuticals to the central nervous system (CNS). Our earlier data exhibited that both the infused volume and the infusion rate can regulate the initial disposition of the administe...

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Detalles Bibliográficos
Autores principales: Belov, Vasily, Appleton, Janine, Levin, Stepan, Giffenig, Pilar, Durcanova, Beata, Papisov, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079755/
https://www.ncbi.nlm.nih.gov/pubmed/33935624
http://dx.doi.org/10.3389/fnins.2021.604197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079755/
https://www.ncbi.nlm.nih.gov/pubmed/33935624
http://dx.doi.org/10.3389/fnins.2021.604197

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