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Large-Volume Intrathecal Administrations: Impact on CSF Pressure and Safety Implications
The increasing number of studies demonstrates the high potency of the intrathecal (IT) route for the delivery of biopharmaceuticals to the central nervous system (CNS). Our earlier data exhibited that both the infused volume and the infusion rate can regulate the initial disposition of the administe...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079755/ https://www.ncbi.nlm.nih.gov/pubmed/33935624 http://dx.doi.org/10.3389/fnins.2021.604197 |