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A Rationally Designed Bovine IgA Fc Scaffold Enhances in planta Accumulation of a V(H)H-Fc Fusion Without Compromising Binding to Enterohemorrhagic E. coli
We previously isolated a single domain antibody (V(H)H) that binds Enterohemorrhagic Escherichia coli (EHEC) with the end-goal being the enteromucosal passive immunization of cattle herds. To improve the yield of a chimeric fusion of the V(H)H with an IgA Fc, we employed two rational design strategi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079772/ https://www.ncbi.nlm.nih.gov/pubmed/33936135 http://dx.doi.org/10.3389/fpls.2021.651262 |