Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies

In diabetes, increased accumulation of sorbitol has been associated with diabetic complications through polyol pathway. Aldose reductase (AR) is one of the key factors involved in reduction of glucose to sorbitol, thereby its inhibition is important for the management of diabetic complications. In t...

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Detalles Bibliográficos
Autores principales: Bacha, Mohsinul Mulk, Nadeem, Humaira, Zaib, Sumera, Sarwar, Sadia, Imran, Aqeel, Rahman, Shafiq Ur, Ali, Hafiz Saqib, Arif, Muazzam, Iqbal, Jamshed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080350/
https://www.ncbi.nlm.nih.gov/pubmed/33906691
http://dx.doi.org/10.1186/s13065-021-00756-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080350/
https://www.ncbi.nlm.nih.gov/pubmed/33906691
http://dx.doi.org/10.1186/s13065-021-00756-z

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