Uncarboxylated osteocalcin alleviates the inhibitory effect of high glucose on osteogenic differentiation of mouse bone marrow–derived mesenchymal stem cells by regulating TP63

BACKGROUND: Progressive population aging has contributed to the increased global prevalence of diabetes and osteoporosis. Inhibition of osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by hyperglycemia is a potential pathogenetic mechanism of osteoporosis in diabetic patients...

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Detalles Bibliográficos
Autores principales: Gong, Fangzi, Gao, Le, Ma, Luyao, Li, Guangxin, Yang, Jianhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080387/
https://www.ncbi.nlm.nih.gov/pubmed/33906607
http://dx.doi.org/10.1186/s12860-021-00365-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080387/
https://www.ncbi.nlm.nih.gov/pubmed/33906607
http://dx.doi.org/10.1186/s12860-021-00365-7

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