Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

A cardinal feature of COVID-19 is lung inflammation and respiratory failure. In a prospective multi-country cohort of COVID-19 patients, we found that increased Notch4 expression on circulating regulatory T (Treg) cells was associated with disease severity, predicted mortality, and declined upon rec...

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Detalles Bibliográficos
Autores principales: Harb, Hani, Benamar, Mehdi, Lai, Peggy S., Contini, Paola, Griffith, Jason W., Crestani, Elena, Schmitz-Abe, Klaus, Chen, Qian, Fong, Jason, Marri, Luca, Filaci, Gilberto, Del Zotto, Genny, Pishesha, Novalia, Kolifrath, Stephen, Broggi, Achille, Ghosh, Sreya, Gelmez, Metin Yusuf, Oktelik, Fatma Betul, Cetin, Esin Aktas, Kiykim, Ayca, Kose, Murat, Wang, Ziwei, Cui, Ye, Yu, Xu G., Li, Jonathan Z., Berra, Lorenzo, Stephen-Victor, Emmanuel, Charbonnier, Louis-Marie, Zanoni, Ivan, Ploegh, Hidde, Deniz, Gunnur, De Palma, Raffaele, Chatila, Talal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080416/
https://www.ncbi.nlm.nih.gov/pubmed/33915108
http://dx.doi.org/10.1016/j.immuni.2021.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080416/
https://www.ncbi.nlm.nih.gov/pubmed/33915108
http://dx.doi.org/10.1016/j.immuni.2021.04.002

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