Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes

Rhodesain is the lysosomal cathepsin L-like cysteine protease of Trypanosoma brucei rhodesiense, the causative agent of Human African Trypanosomiasis. The enzyme is essential for the proliferation and pathogenicity of the parasite as well as its ability to overcome the blood–brain barrier of the hos...

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Detalles Bibliográficos
Autores principales: Johé, Patrick, Jaenicke, Elmar, Neuweiler, Hannes, Schirmeister, Tanja, Kersten, Christian, Hellmich, Ute A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080524/
https://www.ncbi.nlm.nih.gov/pubmed/33745969
http://dx.doi.org/10.1016/j.jbc.2021.100565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080524/
https://www.ncbi.nlm.nih.gov/pubmed/33745969
http://dx.doi.org/10.1016/j.jbc.2021.100565

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