Cargando…

Enzymatically active apurinic/apyrimidinic endodeoxyribonuclease 1 is released by mammalian cells through exosomes

The apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1), the main AP-endonuclease of the DNA base excision repair pathway, is a key molecule of interest to researchers due to its unsuspected roles in different nonrepair activities, such as: i) adaptive cell response to genotoxic stress, ii) regulat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mangiapane, Giovanna, Parolini, Isabella, Conte, Kristel, Malfatti, Matilde Clarissa, Corsi, Jessica, Sanchez, Massimo, Pietrantoni, Agostina, D’Agostino, Vito G., Tell, Gianluca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080531/ https://www.ncbi.nlm.nih.gov/pubmed/33753167 http://dx.doi.org/10.1016/j.jbc.2021.100569

Ejemplares similares

Clinical Significance of Apurinic/Apyrimidinic Endodeoxyribonuclease 1 and MicroRNA Axis in Hepatocellular Carcinoma
por: Mangiapane, Giovanna, et al.
Publicado: (2023)

Serum Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) Level as a Potential Biomarker of Cholangiocarcinoma
por: Tummanatsakun, Doungdean, et al.
Publicado: (2019)

Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells
por: Tummanatsakun, Doungdean, et al.
Publicado: (2021)

Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site
por: Lebedeva, Natalia A., et al.
Publicado: (2021)

Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites
por: Minko, Irina G., et al.
Publicado: (2016)

Identification and Characterization of Inhibitors of Human Apurinic/apyrimidinic Endonuclease APE1
por: Simeonov, Anton, et al.
Publicado: (2009)

Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites
por: Lebedeva, Natalia A., et al.
Publicado: (2012)

Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori
por: Turgimbayeva, Aigerim, et al.
Publicado: (2018)

Total sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleases
por: Schein, Catherine H, et al.
Publicado: (2002)

Apurinic/apyrimidinic endonuclease 1 is a key modulator of aluminum-induced neuroinflammation
por: Zaky, Amira, et al.
Publicado: (2013)

Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg(2+) cofactor
por: Manvilla, Brittney A., et al.
Publicado: (2013)

Apurinic/apyrimidinic endonuclease triggered doxorubicin-releasing DNA nanoprism for target therapy
por: Liang, Meng, et al.
Publicado: (2022)

Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma
por: Xie, Jiayin, et al.
Publicado: (2014)

Cloning and Characterization of a Wheat Homologue of Apurinic/Apyrimidinic Endonuclease Ape1L
por: Joldybayeva, Botagoz, et al.
Publicado: (2014)

Altered Endoribonuclease Activity of Apurinic/Apyrimidinic Endonuclease 1 Variants Identified in the Human Population
por: Kim, Wan Cheol, et al.
Publicado: (2014)

Association of Leukotrichia in Vitiligo and Asp148Glu Polymorphism of Apurinic/Apyrimidinic Endonuclease 1
por: Aydin, A. Fatih, et al.
Publicado: (2017)

Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance
por: Kumar, Subodh, et al.
Publicado: (2018)

Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases
por: Kuznetsova, Alexandra A., et al.
Publicado: (2021)

Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity
por: Dorival, Jonathan, et al.
Publicado: (2023)

Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1)
por: Jackson, Elias B., et al.
Publicado: (2005)

Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies
por: Rajan, Rakhi, et al.
Publicado: (2013)

Prognostic Value of Human Apurinic/Apyrimidinic Endonuclease 1 (APE1) Expression in Breast Cancer
por: Woo, Joohyun, et al.
Publicado: (2014)

Correction: Cloning and Characterization of a Wheat Homologue of Apurinic/Apyrimidinic Endonuclease Ape1L
Publicado: (2014)

Elevation of the Serum Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 in Coronary Artery Disease
por: Jin, Seon-Ah, et al.
Publicado: (2015)

Substrate specificity of human apurinic/apyrimidinic endonuclease APE1 in the nucleotide incision repair pathway
por: Kuznetsova, Alexandra A, et al.
Publicado: (2018)

Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA
por: Barnes, Tavish, et al.
Publicado: (2009)

Identification of a residue critical for the excision of 3′-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family
por: Castillo-Acosta, Víctor M., et al.
Publicado: (2009)

Biochemical properties and base excision repair complex formation of apurinic/apyrimidinic endonuclease from Pyrococcus furiosus
por: Kiyonari, Shinichi, et al.
Publicado: (2009)

High-Resolution Crystal Structures Reveal Plasticity in the Metal Binding Site of Apurinic/Apyrimidinic Endonuclease I
por: He, Hongzhen, et al.
Publicado: (2014)

Endonuclease IV Is the Major Apurinic/Apyrimidinic Endonuclease in Mycobacterium tuberculosis and Is Important for Protection against Oxidative Damage
por: Puri, Rupangi Verma, et al.
Publicado: (2013)

A specific DNA-nanoprobe for tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells
por: Zhai, Junqiu, et al.
Publicado: (2017)

The Role of Active-Site Plasticity in Damaged-Nucleotide Recognition by Human Apurinic/Apyrimidinic Endonuclease APE1
por: Bulygin, Anatoly A., et al.
Publicado: (2020)

Apurinic/Apyrimidinic Endonucleases of Mycobacterium tuberculosis Protect against DNA Damage but Are Dispensable for the Growth of the Pathogen in Guinea Pigs
por: Puri, Rupangi Verma, et al.
Publicado: (2014)

The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes
por: Baek, Hyunjung, et al.
Publicado: (2016)

miR-513a-5p regulates radiosensitivity of osteosarcoma by targeting human apurinic/apyrimidinic endonuclease
por: Dai, Nan, et al.
Publicado: (2016)

Detection of 8-oxoguanine and apurinic/apyrimidinic sites using a fluorophore-labeled probe with cell-penetrating ability
por: Kang, Dong Min, et al.
Publicado: (2019)

Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease
por: Lee, Yu-Ran, et al.
Publicado: (2022)

Kinetic Features of 3′–5′–Exonuclease Activity of Apurinic/Apyrimidinic Endonuclease Apn2 from Saccharomyces cerevisiae
por: Kuznetsova, Aleksandra A., et al.
Publicado: (2022)

Visualizing the coordination of apurinic/apyrimidinic endonuclease (APE1) and DNA polymerase β during base excision repair
por: Fairlamb, Max S., et al.
Publicado: (2023)

Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers
por: Al-Attar, A, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_g4l2pi8ditg81bprtd96t5ov2b