PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs

Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), better known as PKR, plays a key role in the response to viral infections and cellular homeostasis by regulating mRNA translation. Upon binding dsRNA, PKR is activated through homodimerization and subsequent autophosphorylation on...

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Detalles Bibliográficos
Autores principales: Cesaro, Teresa, Hayashi, Yohei, Borghese, Fabian, Vertommen, Didier, Wavreil, Fanny, Michiels, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080564/
https://www.ncbi.nlm.nih.gov/pubmed/33911136
http://dx.doi.org/10.1038/s41598-021-88610-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080564/
https://www.ncbi.nlm.nih.gov/pubmed/33911136
http://dx.doi.org/10.1038/s41598-021-88610-z

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