IP(6)-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion

COP1 and COP9 signalosome (CSN) are the substrate receptor and deneddylase of CRL4 E3 ligase, respectively. How they functionally interact remains unclear. Here, we uncover COP1–CSN antagonism during glucose-induced insulin secretion. Heterozygous Csn2(WT/K70E) mice with partially disrupted binding...

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Detalles Bibliográficos
Autores principales: Lin, Hong, Yan, Yuan, Luo, Yifan, So, Wing Yan, Wei, Xiayun, Zhang, Xiaozhe, Yang, Xiaoli, Zhang, Jun, Su, Yang, Yang, Xiuyan, Zhang, Bobo, Zhang, Kangjun, Jiang, Nan, Chow, Billy Kwok Chong, Han, Weiping, Wang, Fengchao, Rao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080631/
https://www.ncbi.nlm.nih.gov/pubmed/33911083
http://dx.doi.org/10.1038/s41467-021-22941-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080631/
https://www.ncbi.nlm.nih.gov/pubmed/33911083
http://dx.doi.org/10.1038/s41467-021-22941-3

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