Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance

Homologous recombination (HR) repair deficiency impairs the proper maintenance of genomic stability, thus rendering cancer cells vulnerable to loss or inhibition of DNA repair proteins, such as poly(ADP-ribose) polymerase-1 (PARP-1). Inhibitors of nuclear PARPs are effective therapeutics for a numbe...

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Detalles Bibliográficos
Autores principales: Kim, Dae-Seok, Camacho, Cristel V., Kraus, W. Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080675/
https://www.ncbi.nlm.nih.gov/pubmed/33487630
http://dx.doi.org/10.1038/s12276-021-00557-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080675/
https://www.ncbi.nlm.nih.gov/pubmed/33487630
http://dx.doi.org/10.1038/s12276-021-00557-3

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