Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining

The mutational mechanisms underlying recurrent deletions in clonal hematopoiesis are not entirely clear. In the current study we inspect the genomic regions around recurrent deletions in myeloid malignancies, and identify microhomology-based signatures in CALR, ASXL1 and SRSF2 loci. We demonstrate t...

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Detalles Bibliográficos
Autores principales: Feldman, Tzah, Bercovich, Akhiad, Moskovitz, Yoni, Chapal-Ilani, Noa, Mitchell, Amanda, Medeiros, Jessie J. F., Biezuner, Tamir, Kaushansky, Nathali, Minden, Mark D., Gupta, Vikas, Milyavsky, Michael, Livneh, Zvi, Tanay, Amos, Shlush, Liran I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080710/
https://www.ncbi.nlm.nih.gov/pubmed/33911081
http://dx.doi.org/10.1038/s41467-021-22803-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080710/
https://www.ncbi.nlm.nih.gov/pubmed/33911081
http://dx.doi.org/10.1038/s41467-021-22803-y

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