Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells

The eukaryotic elongation factor-2 kinase, eEF2K, which restricts protein translation elongation, has been identified as a potential therapeutic target for diverse types of malignancies including triple negative breast cancer (TNBC). However, the contexts in which eEF2K inhibition is essential in TN...

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Detalles Bibliográficos
Autores principales: Ju, YoungJun, Ben-David, Yaacov, Rotin, Daniela, Zacksenhaus, Eldad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080725/
https://www.ncbi.nlm.nih.gov/pubmed/33911160
http://dx.doi.org/10.1038/s41598-021-88816-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080725/
https://www.ncbi.nlm.nih.gov/pubmed/33911160
http://dx.doi.org/10.1038/s41598-021-88816-1

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