EGFR/FOXO3a/BIM signaling pathway determines chemosensitivity of BMP4-differentiated glioma stem cells to temozolomide

Accumulating evidence suggests that glioma stem cells (GSCs), which are rare cells characterized by pluripotency and self-renewal ability, are responsible for glioblastoma (GBM) propagation, recurrence and resistance to therapies. Bone morphogenic proteins (BMPs) induce GSC differentiation, which le...

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Detalles Bibliográficos
Autores principales: Ciechomska, Iwona Anna, Gielniewski, Bartlomiej, Wojtas, Bartosz, Kaminska, Bozena, Mieczkowski, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080762/
https://www.ncbi.nlm.nih.gov/pubmed/32788653
http://dx.doi.org/10.1038/s12276-020-0479-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080762/
https://www.ncbi.nlm.nih.gov/pubmed/32788653
http://dx.doi.org/10.1038/s12276-020-0479-9

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