Cargando…
Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling
The importance of modulating the intensity of Wnt signaling has been highlighted in various biological models, but their mechanisms remain unclear. In this study, we found that Ryk—an atypical Wnt receptor with a pseudokinase domain—has a Wnt-modulating effect in bone marrow stromal cells to control...
Autores principales: | Jeong, Seon-Yeong, Lyu, Jungmook, Kim, Jin-A, Oh, Il-Hoan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080773/ https://www.ncbi.nlm.nih.gov/pubmed/32724069 http://dx.doi.org/10.1038/s12276-020-0477-y |
Ejemplares similares
-
WNT/RYK signaling functions as an antiinflammatory modulator in the lung mesenchyme
por: Kim, Hyun-Taek, et al.
Publicado: (2022) -
The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis
por: Famili, Farbod, et al.
Publicado: (2016) -
Non-Canonical WNT5A Signaling Through RYK Contributes to Aggressive Phenotype of the Rheumatoid Fibroblast-Like Synoviocytes
por: Rodriguez-Trillo, Angela, et al.
Publicado: (2020) -
Mesenchymal niche: the sensor and effector of leukemogenesis
por: Oh, Il-Hoan
Publicado: (2015) -
A Fully Human Inhibitory Monoclonal Antibody to the Wnt Receptor RYK
por: Halford, Michael M., et al.
Publicado: (2013)