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The dopamine D1–D2DR complex in the rat spinal cord promotes neuropathic pain by increasing neuronal excitability after chronic constriction injury
Dopamine D1 receptor (D1DR) and D2 receptor (D2DR) are closely associated with pain modulation, but their exact effects on neuropathic pain and the underlying mechanisms remain to be identified. Our research revealed that intrathecal administration of D1DR and D2DR antagonists inhibited D1–D2DR comp...
Autores principales: | Bao, Yi-Ni, Dai, Wen-Ling, Fan, Ji-Fa, Ma, Bin, Li, Shan-Shan, Zhao, Wan-Li, Yu, Bo-Yang, Liu, Ji-Hua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080784/ https://www.ncbi.nlm.nih.gov/pubmed/33558591 http://dx.doi.org/10.1038/s12276-021-00563-5 |
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