The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation

Targeting cancer metabolism has emerged as an important cancer therapeutic strategy. Here, we describe the synthesis and biological evaluation of a novel class of hypoxia-inducible factor (HIF)-1α inhibitors, disubstituted adamantyl derivatives. One such compound, LW1564, significantly suppressed HI...

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Detalles Bibliográficos
Autores principales: Kim, Inhyub, Kim, Minkyoung, Park, Min Kyung, Naik, Ravi, Park, Jae Hyung, Kim, Bo-Kyung, Choi, Yongseok, Chang, Kwan Young, Won, Misun, Ban, Hyun Seung, Lee, Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080809/
https://www.ncbi.nlm.nih.gov/pubmed/33235318
http://dx.doi.org/10.1038/s12276-020-00523-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080809/
https://www.ncbi.nlm.nih.gov/pubmed/33235318
http://dx.doi.org/10.1038/s12276-020-00523-5

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