Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1

Until recently, Nurr1 (NR4A2) was known as an orphan nuclear receptor without a canonical ligand-binding domain, featuring instead a narrow and tight cavity for small molecular ligands to bind. In-depth characterization of its ligand-binding pocket revealed that it is highly dynamic, with its struct...

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Detalles Bibliográficos
Autores principales: Jang, Yongwoo, Kim, Woori, Leblanc, Pierre, Kim, Chun-Hyung, Kim, Kwang-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080818/
https://www.ncbi.nlm.nih.gov/pubmed/33479411
http://dx.doi.org/10.1038/s12276-021-00555-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080818/
https://www.ncbi.nlm.nih.gov/pubmed/33479411
http://dx.doi.org/10.1038/s12276-021-00555-5

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