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Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action
A joint analysis of the NCI60 small molecule screening data, their genetically defective genes, and mechanisms of action (MOA) of FDA approved cancer drugs screened in the NCI60 is proposed for identifying links between chemosensitivity, genomic defects and MOA. Self-Organizing-Maps (SOMs) are used...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081165/ https://www.ncbi.nlm.nih.gov/pubmed/33909629 http://dx.doi.org/10.1371/journal.pone.0243336 |