Pooled CRISPR screening identifies m(6)A as a positive regulator of macrophage activation

m(6)A RNA modification is implicated in multiple cellular responses. However, its function in the innate immune cells is poorly understood. Here, we identified major m(6)A “writers” as the top candidate genes regulating macrophage activation by LPS in an RNA binding protein focused CRISPR screening....

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Detalles Bibliográficos
Autores principales: Tong, Jiyu, Wang, Xuefei, Liu, Yongbo, Ren, Xingxing, Wang, Anmin, Chen, Zonggui, Yao, Jiameng, Mao, Kaiqiong, Liu, Tingting, Meng, Fei-Long, Pan, Wen, Zou, Qiang, Liu, Jun, Zhou, Yu, Xia, Qiang, Flavell, Richard A., Zhu, Shu, Li, Hua-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081357/
https://www.ncbi.nlm.nih.gov/pubmed/33910903
http://dx.doi.org/10.1126/sciadv.abd4742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081357/
https://www.ncbi.nlm.nih.gov/pubmed/33910903
http://dx.doi.org/10.1126/sciadv.abd4742

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