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Pooled CRISPR screening identifies m(6)A as a positive regulator of macrophage activation
m(6)A RNA modification is implicated in multiple cellular responses. However, its function in the innate immune cells is poorly understood. Here, we identified major m(6)A “writers” as the top candidate genes regulating macrophage activation by LPS in an RNA binding protein focused CRISPR screening....
Autores principales: | Tong, Jiyu, Wang, Xuefei, Liu, Yongbo, Ren, Xingxing, Wang, Anmin, Chen, Zonggui, Yao, Jiameng, Mao, Kaiqiong, Liu, Tingting, Meng, Fei-Long, Pan, Wen, Zou, Qiang, Liu, Jun, Zhou, Yu, Xia, Qiang, Flavell, Richard A., Zhu, Shu, Li, Hua-Bing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081357/ https://www.ncbi.nlm.nih.gov/pubmed/33910903 http://dx.doi.org/10.1126/sciadv.abd4742 |
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