A comparative analysis of the mutagenicity of platinum-containing chemotherapeutic agents reveals direct and indirect mutagenic mechanisms

Platinum-based drugs are a mainstay of cancer chemotherapy. However, their mutagenic effect can increase tumour heterogeneity, contribute to the evolution of treatment resistance and also induce secondary malignancies. We coupled whole genome sequencing with phenotypic investigations on two cell lin...

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Detalles Bibliográficos
Autores principales: Szikriszt, Bernadett, Póti, Ádám, Németh, Eszter, Kanu, Nnennaya, Swanton, Charles, Szüts, Dávid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Regular Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081379/
https://www.ncbi.nlm.nih.gov/pubmed/33502495
http://dx.doi.org/10.1093/mutage/geab005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081379/
https://www.ncbi.nlm.nih.gov/pubmed/33502495
http://dx.doi.org/10.1093/mutage/geab005

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