Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

Nucleotide-binding domain, leucine-rich repeat receptors (NLRs) mediate innate immunity by forming inflammasomes. Activation of the NLR protein NLRP1 requires autocleavage within its function-to-find domain (FIIND)(1–7). In resting cells, the dipeptidyl peptidases DPP8 and DPP9 interact with the FII...

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Detalles Bibliográficos
Autores principales: Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081665/
https://www.ncbi.nlm.nih.gov/pubmed/33731929
http://dx.doi.org/10.1038/s41586-021-03320-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081665/
https://www.ncbi.nlm.nih.gov/pubmed/33731929
http://dx.doi.org/10.1038/s41586-021-03320-w

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