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Structural and biochemical mechanisms of NLRP1 inhibition by DPP9
Nucleotide-binding domain, leucine-rich repeat receptors (NLRs) mediate innate immunity by forming inflammasomes. Activation of the NLR protein NLRP1 requires autocleavage within its function-to-find domain (FIIND)(1–7). In resting cells, the dipeptidyl peptidases DPP8 and DPP9 interact with the FII...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081665/ https://www.ncbi.nlm.nih.gov/pubmed/33731929 http://dx.doi.org/10.1038/s41586-021-03320-w |